CLAY, Circuit Judge. Plaintiffs Kenneth M. Miller and House of Glunz, Inc. challenge the constitutionality of Ohio liquor laws preventing out-of-state wine retailers from shipping wine directly to Ohio consumers, Ohio Rev. Code Ann. §§ 4301.01(A)(2), 4303.03, 4303.12, 4303.27 (the “Direct Ship Restriction”), and prohibiting individuals from transporting more than 4.5 liters of wine into Ohio during any 30-day period, Ohio Rev. Code Ann. § 4301.20(L) (the “Transportation Limit”).1 Through this appeal, Plaintiffs challenge the district court’s holdings that: (1) the Direct Ship Restriction is constitutional under binding Sixth Circuit precedent; (2) the Director of the Ohio Department of Public Safety is entitled to Eleventh Amendment immunity from Plaintiffs’ claims; and (3) Plaintiffs lack standing to challenge the Transportation Limit. For the reasons set forth below, we AFFIRM IN PART and REVERSE IN PART.